CEFPIROME SULFATE

PRODUCT IDENTIFICATION

CAS NO. 84957-29-9 (parent), 98753-19-6 (sulfate)

CEFPIROME 

EINECS NO.  
FORMULA C21H23N7O9S3
MOL WT. 613.64

H.S. CODE

 

TOXICITY

 

PRICE

 

SYNONYMS Cefrom;
1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia- 1-azabicyclo(4.2.0)oct- 2-en-3-yl)methyl)-6,7-dihydro-5H-1-pyrindinium hydroxide, inner salt, 7(sup 2)-(Z)-(O-methyloxime), sulfate (1:1); (6R,7R)-7-(()-2-(2-Amino-4-thiazolyl)-2- methoxyiminoacetamido) -8-oxo-3-(2beta- trimethylenpyridinio) methyl)-5-thia- 1-azabicyclo(4.2.0)oct-2-en-2-carboxylate sulfuric acid;

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

off white to pale yellow powder

MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

"Cefpirome is a bactericidal β-lactamase-stable cephalosporin antibiotic. As a β-lactam, it acts by disturbing the synthesis of the main bacterial cell-wall polymer, peptidoglycan. It is bactericidal at low concentrations against an extremely broad spectrum of gram-negative and gram-positive pathogens because it penetrates the cell wall of bacteria extremely rapidly and binds to the target enzymes (penicillin-binding proteins) with high affinity. Cefpirome is very stable against hydrolysis by broad spectrum plasmid-mediated and chromosomally-mediated β-lactamases and compared to third generation cephalosporins, has a lower affinity for these enzymes and is less likely to select active hyper producer mutants. Furthermore cefpirome is more active against de-repressed mutants producing high level of cephalosporinase than third generation cephalosporins. Cefpirome shows synergistic activity with aminoglycosides against many bacteria." source: http://www.medsafe.govt.nz/profs/Datasheet/discontinued/Cefrominj.htm

SALES SPECIFICATION

APPEARANCE

off white to pale yellow powder

CEFPIROME CONTENT

67.5% - 75.0%

LOSS ON DRYING

2.5% max

ASSAY

82.5% min (on anhydrous basis)

TRANSPORTATION
PACKING
 
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OTHER INFORMATION