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CEFPIROME SULFATE | ||
PRODUCT IDENTIFICATION |
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CAS NO. | 84957-29-9 (parent), 98753-19-6 (sulfate) |
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EINECS NO. | ||
FORMULA | C21H23N7O9S3 | |
MOL WT. | 613.64 | |
H.S. CODE |
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TOXICITY |
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PRICE |
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SYNONYMS | Cefrom; | |
1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia- 1-azabicyclo(4.2.0)oct- 2-en-3-yl)methyl)-6,7-dihydro-5H-1-pyrindinium hydroxide, inner salt, 7(sup 2)-(Z)-(O-methyloxime), sulfate (1:1); (6R,7R)-7-(()-2-(2-Amino-4-thiazolyl)-2- methoxyiminoacetamido) -8-oxo-3-(2beta- trimethylenpyridinio) methyl)-5-thia- 1-azabicyclo(4.2.0)oct-2-en-2-carboxylate sulfuric acid; | ||
CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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PHYSICAL STATE |
off white to pale yellow powder | |
MELTING POINT | ||
BOILING POINT | ||
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SOLUBILITY IN WATER | ||
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AUTOIGNITION |
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NFPA RATINGS |
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REFRACTIVE INDEX |
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FLASH POINT |
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STABILITY |
Stable under ordinary conditions | |
GENERAL DESCRIPTION & APPLICATIONS |
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"Cefpirome is a bactericidal β-lactamase-stable cephalosporin antibiotic. As a β-lactam, it acts by disturbing the synthesis of the main bacterial cell-wall polymer, peptidoglycan. It is bactericidal at low concentrations against an extremely broad spectrum of gram-negative and gram-positive pathogens because it penetrates the cell wall of bacteria extremely rapidly and binds to the target enzymes (penicillin-binding proteins) with high affinity. Cefpirome is very stable against hydrolysis by broad spectrum plasmid-mediated and chromosomally-mediated β-lactamases and compared to third generation cephalosporins, has a lower affinity for these enzymes and is less likely to select active hyper producer mutants. Furthermore cefpirome is more active against de-repressed mutants producing high level of cephalosporinase than third generation cephalosporins. Cefpirome shows synergistic activity with aminoglycosides against many bacteria." source: http://www.medsafe.govt.nz/profs/Datasheet/discontinued/Cefrominj.htm |
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SALES SPECIFICATION | ||
APPEARANCE |
off white to pale yellow powder |
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CEFPIROME CONTENT |
67.5% - 75.0% |
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LOSS ON DRYING |
2.5% max |
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ASSAY |
82.5% min (on anhydrous basis) |
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TRANSPORTATION | ||
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OTHER INFORMATION | ||
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